What Causes Type 1 Diabetes?

Type 1 Diabetes: Causes. Autoimmunity. Vaccine Safety. Progression.


Why are children prone to type 1 diabetes?
Is it an autoimmune disease, a genetic disorder or a complication of childhood infections?
Are vaccines safe for children?
Oh! So many questions cloud parents mind.
Naturally so! It does get confusing.
Frequently a new trigger factor is linked to childhood diabetes. Moreover, more and more children are being diagnosed to be suffering from this incurable chronic disease. 

Insulin dependent diabetes

  • Regular and well monitored insulin replacement therapy helps children with type 1 diabetes (T1D) lead an active normal life, but the disease is not curable.

  • In spite of all precautions taken intermittent blood sugar imbalances are common, and complication often set in over years. 

  • Children with type 1 diabetes are therefore dependent on insulin supplementation to maintain their round the clock blood sugar levels.

Causative factors simplified

Disturbed physiology of T1D sets in much before the clinical presentation of the disease, usually in early childhood; 85% of teenagers and children with diabetes suffer from from T1D.  It is therefore commonly known as “Juvenile Diabetes”. 

Juvenile diabetes is multifactorial metabolic disorder.

It is caused by complex interaction of child’s innate genetic predisposition and environmental factors that accidentally trigger body’s immune system. But then autoimmunity markers are much more prevalent than the disease itself, which indicate that trigger of autoimmunity is essential but not a sufficient cause for development of clinical childhood diabetes.

Type 1 Diabetes Pathogenesis

Liked what you read just now? Pay it forward!

Have Questions? Ask the Expert and have Your Answers for Free

Genetic concept

  • Many different genetic loci determine child’s susceptibility to diabetes, but all genetically predisposed children do not develop the disease.

  • Genetic predisposition only increases the chances of developing juvenile diabetes:
    Even an identical twin of a diabetic child has only 30-60% chances of developing the disease.

  • Genetic predisposition accounts for only a quarter of all type 1 diabetes patients.

  • Risk associated with familial predisposition:
    Siblings of a diabetic are at 15-20 fold higher risk for developing the disease when compared with that in general population. Same is true for children whose parents are known to be diabetic. Statistically the chances of child developing clinical diabetes is yet 3 fold higher if the father is a diabetic than if the mother is a diabetic. And 3% of the parents of children with diabetes later develop the disease.

Click Here to Post your Questions: It's Free

Type 1 Diabetes: Causes. Autoimmunity. Vaccine Safety. Progression.

Related pages of interest are indexed in the right column

Back To 
Childhood Diabetes

Liked what you read just now? Pay it forward!

Can't find answer to your concern? Search the site!

New! Comments

Have your say about what you just read! Leave me a comment in the box below.
Child Health Explanation

Child Health Explanation

Home Page

Child Health Explanation

Follow Me

Liked What You Just Read?
Pay It Forward

Related Pages



Fetal Viability

Morbidity & Mortality

Fetal Growth

Mother's Nutrition

Folic Acid Supplementation

Fetal Growth Chart


Uterine fundal height

Ultrasound evaluations

Causes for concern

Causes of large for date baby

Causes of small for date baby

Threats to Fetal Development

Stress and fatigue

Sleep and snoring

Spacing pregnancies

Infections in mother


Do's and Don'ts

Drug Induced Birth Defects

Obesity in Mothers Hampers .....

IVF Affects Child Health

Alcohol in Pregnancy

Fetal Alcohol Syndrome

Severity groups of FAS


Mode of effect on fetus

Effects of alcohol on fetus

Preventive? Yes

Treatment - only supportive

Mothers Who Drink Alcohol Beware

Coffee During Pregnancy

Why restrict?

Caffeine & newborns' aponea

Mode of effect on fetus

Effects on mother's nutrition

Mother's blood circulation

Decaf coffee

Itching in Pregnancy - Baby's Way to Alert Mother 

Exercising During Pregnancy

Exposure to mold in pregnancy

Diabetes Related

Childhood diabetes

Insulin Resistance

Type 1 Diabetes: Causative Factors

Type 1 Diabetes: Progression

Type 1 Diabetes & Autoimmunity

Diabetic Retinopathy

Vaccine Safety

Prevention of Diabetes

Diabetic Retinopathy

Diabetic Eye: Glaucoma

Diabetic Cataract

Diabetes During Pregnancy

High Fructose Corn Syrup in Diet 

Obesity And Diabetes: How Strong Is The Link

Liked What You Just Read?
Pay It Forward